I’ve seen a number of cases where Exchange Information Stores are located on SANs. If you don’t have enough throughput you’re likely to see RPC request timeouts for the database, mailboxes or even a server. This typically correlates to Event IDs of 10025, 10026 and 10027. If a mailbox is having such problems then it will be quarantined. If you have this happen once or twice then it’s likely not that big of a deal. However, if it happens repeatedly then you’ve likely got a problem. These can be cumbersome to fix. So while you’re working on things, rather than have mailboxes go offline all the time, you can edit…